spinosad trade name

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. When do Natroba patents expire, and what generic alternatives are available? In Europe, pyriproxyfen is known under the brand names Cyclio and Exil Flea Free TwinSpot (Emax). Your search for: "Spinosad" "Gf-120 nf naturalyte fruit fly bait" has produced 18 results. It is used to control a wide variety of pests. Brand names: Natroba. [5] Two other uses for spinosad are for pets and humans. Several spinosad formulations under the trade name Natular, ranging from fast release emulsifiable concentrate and granules to slow release tablets and briquets, have been registered for mosquito control in the United States and elsewhere (Clarke, Roselle, IL). Forosamine at the 17-position of spinosyns A and D was hydrolyzed under mild acidic conditions to give the corresponding 17-pseudoaglycones. Abamectin, Avid as it is often referred to in the generic, is an insecticide, acaricide and nematicide most commonly used by gardeners and the agriculture industry to fight off mites. Lice. Spinosad 45% SC is a natural substance made by a soil bacterium that can be toxic to insects. CAS number: 168316-95-8 . IUPAC name: Spinosad as a mixture of 50-95 % spinosyn A and 5-50 % spinosyn D. EC number:-; 434-300-1 . Spinosad is a mixture of spinosyn A and spinosyn D. Chemical name ... Trade names: Success, Tracer, Spintor, Spinoace, Boomerang, Laser, Extinosad Structural formula: Spinosyn A O O O O O H H H H H CH 3 O CH 3 O CH CH 3O 3 OCH 3 CH 3 2 (CH 3) 2N OCH 3. Look for spinosad under the following trade names: Monterey Garden Insect SprayR, Ferti-lomeR Borer, Bagworm, Leafminer & Tent Caterpillar Spray, and Bulls-EyeTM Bioinsecticide. [4] Spinosad contains a mix of two spinosoids, spinosyn A, the major component, and spinosyn D (the minor component), in a roughly 17:3 ratio. The tri-O-methylrhamnose at the 9-position of the 17-pseudoaglycone of spinosyn A was hydrolyzed under more vigorous acidic conditions to give the aglycone of spinosyn A. [7] The apparent lack of spinosyn A metabolism may contribute to its high level of activity, and may compensate for the slow rate of penetration. The genus Saccharopolyspora was discovered in 1985 in isolates from crushed sugarcane. [8] Its labeled use rate is set at 1 ppm (1 mg a.i./kg of grain) and its maximum residue limit (MRL) or tolerance is set at 1.5 ppm. [4] Spinosyn A is highly active against neonate larvae of the tobacco budworm, Heliothis virescens, and is slightly more biologically active than spinosyn D. In general, spinosyns possessing a methyl group at C6 (spinosyn D-related analogs) tend to be more active and less affected by changes in the rest of the molecule. Example home, garden or landscape use products 6. Spinosad 0.9% topical suspension is used to treat head lice infestations. Suspension, External: Natroba: 0.9% (120 mL) [contains benzyl alcohol, cetearyl alcohol, fd&c yellow #6 (sunset yellow), isopropyl alcohol, propylene glycol] Generic: 0.9% (120 mL) Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Pyriproxyfen has low acute toxicity. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Spinosad is a macrocyclic lactone and therefore should in theory be contraindicated for use on dogs with the MDR-1 mutation (see Chapter 5: Vulnerable Patients). We comply with the HONcode standard for trustworthy health information -, Search the entire Drugs.com site for spinosad. [5] Its overall protective effect varies with insect species and life stage. [8] Spinosad residues are highly stable on grains stored in bins, with protection ranging from 6 months to 2 years. S.No. Chemical formula: C83H132N2O20Drugbank ID: DB08823. Therapeutic effects Eradication of head lice. Active Substance details. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Spinosoid binding leads to disruption of acetylcholine neurotransmission. [6] Spinosyn A resembles a GABA antagonist and is comparable to the effect of avermectin on insect neurons. Trade Name: Antixx Liquid Ant Bait Active Ingredient: Spinosad Supplier Info: W. Neudorff GmbH KG An der Muhle 3 Emmerthal 31860 Germany Office 250-652-5888 Labels: SC […] SPINOSAD (203) IDENTITY ... ISO common name: spinosad. Min.Order: 1 Kilogram FOB Price: USD $ 1.0-3.0/Kilogram hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm In the US, pyriproxyfen is often marketed under the trade name Nylar. [2] Spinosad also has secondary effects as a γ-amino-butyric acid (GABA) neurotransmitter agonist. Spinosad's widespread commercial launch was deferred, awaiting final MRL or tolerance approvals in a few remain… Seduce OG (spinosad): An insecticidal bait derived from the soil bacterium Saccharopolyspora spinosa; acts as a nerve and stomach poison. US Brand Name. [7] Spinosyn A is slow to penetrate to the internal fluids of larvae; it is also poorly metabolized once it enters the insect. How the information is presented. NDC Product Information Natroba with NDC 52246-929 is a a human prescription drug product labeled by Parapro Llc. Spinosad has a unique mode of action that is different from all other known insect control products.It represents a new class of highly effective and safest insect control agent with superior and consistent control. Attracts and kills insects feeding on or near the base of plants. Spread the knowledgeHi all, I have collected a list of all the major insecticides available in the market and arranged them in a learn-able organized tabular form. Trade name: BOITES ANTI-FOURMIS. Spinosad is a natural substance made by a soil bacterium that can be toxic to insects. Spinosad is a mixture of chemical compounds in the spinosyn family that has a generalized structure consisting of a unique tetracyclic ring system attached to an amino sugar (D-forosamine) and a neutral sugar (tri-Ο-methyl-L-rhamnose). [15] Similarly, administration of 25 mg/kg/day to rats for 24 months did not result in tumor formation. Spinosad is a natural substance made by a soil bacterium that can be toxic to insects. It is a mixture of two chemicals called spinosyn A and spinosyn D. It is used to control a wide variety of pests. Fire Ants, spider mites, and reproductive toxins… This drug has forty-eight patent family members in thirty countries. (g)/Ha Formulation Requirement / Ha Scope Triangle 1 Pryriproxifen 10% SC Lano Sumitomo Chem. spinosad topical. The results table presents information on an active substance, such as approval start and end date, evaluating competent authority and approval or assessment status. [1], Spinosad is highly active, by both contact and ingestion, in numerous insect species. [11][12][13], Spinosyn A does not appear to interact directly with known insecticidal-relevant target sites, but rather acts via a novel mechanism. Natroba; Descriptions. Uses. Spinosad is a metabolite produced by fermentation of the naturally occurring soil bacteria Saccharopolyspora spinosa. Spinosad controls a wide variety of pests including fleas, caterpillars, fruit flies, spider mites, fire ants, leaf beetle larvae, thrips, leaf miners and leaf beetle larvae to name only a few.It is recommended as one component of Integrated Pest Management for greenhouses because it does not target beneficial insects such as ladybugs and predatory mites. Spinosad has recently been used in oral preparations (as Comfortis) to treat C. felis, the cat flea, in canines and felines; the optimal dose set for canines is reported to be 30 mg/kg. Spinosad is also commonly used to kill thrips. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Spinosad can enhance the toxicity of ivermectin when used at a high dose (e.g., 0.6 mg/kg, against demodicosis) so it should not be administered in conjunction with ivermectin. - Related authorised biocidal products (trade name of a biocidal product). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. [5] It is regarded as natural product-based, and approved for use in organic agriculture by numerous national and international certifications. The active ingredient in Entrust SC Naturalyte is spinosad. Conserve SC Spinosad/spintor Spinosyn A and Spinosyn D 5 Dow AgroSciences Coragen Chlorantraniliprole 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide 28 Dupont Co-Ral Coumaphos O,O-diethyl O-(3-chloro-4-methyl-2-oxo2H-1-enzopyuran 7-yl- phosphorothioate 1B Bayer Corporation nov. Isolated from soil Collected in a Sugar Mill Rum Still", 10.1002/1526-4998(200102)57:2<177::AID-PS281>3.0.CO;2-Z, "Spinosad: A new natural product for stored grain protection", "Resistance and cross-resistance to the spinosyns- A review and analysis", "Safer Flea Control | Insects in the City", "Codling Moth and Leafroller Control Using Chemicals", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in CD-1 Mice", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in Fischer 344 Rats", https://en.wikipedia.org/w/index.php?title=Spinosad&oldid=998542987, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Chemical articles with multiple PubChem CIDs, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Wikipedia articles needing clarification from June 2014, Creative Commons Attribution-ShareAlike License, This page was last edited on 5 January 2021, at 21:34. supplier Spinosad 168316-95-8. [5][clarification needed] Toxicity in mammals. Techincal Name Trade Name Manfacturer / Distributor General Code for Pesticide Formulation a.i. 52 … It was first registered as a pesticide in the United States for use on crops in 1997. It works by causing nervous system excitation in insects. Common, Chemical and Trade Names of Insecticides Used in this Guide Trade Common Name Chemical Name IRAC Classification Company Abate Temephos O,O -(thiodi-4,1-phenylene) O,O, O' O'-tetramethyl phosphorothioate 1B BASF Corporation Abba Abamectin a mixture of avermectin B1a (10E,14E,16E,22Z)- These include thrips, leafminers, spider mites, mosquitoes, ants, fruit flies and others.Many products containing spinosad are used on crops and ornamental plants. [2] Spinosad so far has proven not to cause cross-resistance to any other known insecticide. Tradename (spinosad) Suspension, 0.9% was demonstrated to be statistically superior to an active comparator NIX (permethrin 1%) in each of two well-controlled pivotal, Phase 3 trials. Some of these products are approved for use in organic agriculture. [2] Spinosad is relatively nonpolar and not easily dissolved in water. Natroba is sold for treatment of human head lice. It affects certain species only in the adult stage, but can affect other species at more than one life stage. Product-type: PT18. The generic ingredient in NATROBA is spinosad.There is one drug master file entry for this compound. Comfortis and Trifexis brands treat adult fleas on pets; the latter also prevents heartworm disease. Drug class (es): topical anti-infectives. S. spinosa was isolated from soil collected inside a nonoperational sugar mill rum still in the Virgin Islands. Tracer is comprised primarily of two macrocyclic lactones, Spinosyn A and D, secondary metabolites produced by the actinomycete, Saccharopolyspra spinosa under natural fermentation condition. Because spinosad is a relatively new compound, it's not yet found its way onto many garden store shelves. Spinosad topical is used in the treatment of: Head Lice. Its labeled use rate is set at 1 ppm (1 mg a.i./kg of grain) and its maximum residue limit (MRL) or tolerance is set at 1.5 ppm. Spinosad works by contact and by ingestion. Trade name: Tracer® Common name: Spinosad 24% Suspension Concentrate (SC). 2 Spinosad is an aerobic fermentation product of the soil bacterium, ... 32 Chemical Names: The name spinosad is derived from 33 combining the characters from spinosyn A and spinosyn 34 D. The material is a mixture of about 85% Spinosyn A ... 51 Trade Names: Tracer, Success, Conserve, Spintor. … spinosad ( spy -no-sad) , Natroba (trade name) Classification Therapeutic: pediculocides Pregnancy Category: B Indications Treatment of head lice in adults and children >4 yr. Action Causes neuronal hyperexcitation in insects, resulting paralysis and death of lice. [9][10] Trifexis also includes milbemycin oxime. Its chemical name is Spinosyn A where as its molecular formula is … [6] The spinosyns and spinosoids have a novel mode of action, primarily targeting binding sites on nicotinic acetylcholine receptors (nAChRs) of the insect nervous system that are distinct from those at which other insecticides have their activity. Important: The information below refers to products available in the United States that contain spinosad. The bacteria produce yellowish-pink aerial hyphae, with bead-like chains of spores enclosed in a characteristic hairy sheath. Spinosad was obtained from Dow Agro Sciences (Indianapolis, IN), and the pyrethrins was from McLaughlin Gormley King (Minneapolis, MN). Available for Android and iOS devices. The species subject to very high rates of mortality as larvae, but not as adults, may gradually be controlled through sustained larval mortality. There are two patents protecting this drug. BAS number: 49 . [16], InChI=1S/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1, (A): InChI=1/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1, Except where otherwise noted, data are given for materials in their, The non‐target impact of spinosyns on beneficial arthropods, Spinosad toxicity to pollinators and associated risk, "Saccharopolyspora spinosa sp. [7], Spinosad has high efficacy, a broad insect pest spectrum, low mammalian toxicity, and a good environmental profile, a unique feature of the insecticide compared to others currently used for the protection of grain products. Spinosad is an outstanding pesticide used in agriculture to control over pest and for increase the production. It is considered a natural product, thus is approved for use in organic agriculture by numerous nations. Class : Common Name : Trade Name-----I piperonyl butoxide Butacide, Incite I potassium salts Safer Insecticidal Soap F potassium bicarbonate Kaligreen [5] The mode of action of spinosoid insecticides is by a neural mechanism. [3], Spinosad is a novel mode-of-action insecticide derived from a family of natural products obtained by fermentation of S. spinosa. Spinosad's widespread commercial launch was deferred, awaiting final MRL or tolerance approvals in a few remaining grain-importing countries. Spinosad, comprising spinosyn A and spinosyn D in a ratio of approximately 85:15, is the active ingredient in the formulations TRACER and LASER. Substance name: Spinosad. Information about pesticides used in urban situations. These include thrips, leafminers, spider mites, mosquitoes, ants, fruit flies and others. Ecotoxicology parameters have been reported for spinosad, and are:[14], Chronic exposure studies failed to induce tumor formation in rats and mice; mice given up to 51 mg/kg/day for 18 months resulted in no tumor formation. [1] This genus is defined as aerobic, Gram-positive, nonacid-fast actinomycetes with fragmenting substrate mycelium. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. The product's dosage form is suspension and is administered via topical form. However, these conditions led to decomposition of the 17-pseudoaglycone of … Spinosad(Natroba) generic is a pediculicide (a topical suspension), prescribed for head lice. Spinosyns occur in over 20 natural forms, and over 200 synthetic forms (spinosoids) have been produced in the lab. This product is available in EC(Emulsifiable Concentrate),SC(Suspension Concentrate) form. TRACER is an suspension concentrate formulation with 480 g ai.L-1, while LASER is an aqueous suspension emulsion in oil with 125 g ai.L-1. The generic name of Natroba is spinosad. Spinosad topical suspension, 0.9%, was approved by the U.S. Food and Drug Administration (FDA) on 2011-01-18 for the topical treatment of head lice infestation in patients four (4) years of age and older. Known as a developmental or reproductive toxin in humans, this chemical is highly toxic to aquatic life. Spinosad is an insecticide based on chemical compounds found in the bacterial species Saccharopolyspora spinosa. [2] It kills insects by hyperexcitation of the insect nervous system. [8] It was first registered as a pesticide in the United States for use on crops in 1997. Brand names: NatrobaDrug class(es): topical anti-infectivesSpinosad topical is used in the treatment of: → Search the entire Drugs.com site for spinosad. [7], Spinosad has been used around the world for the control of a variety of insect pests, including Lepidoptera, Diptera, Thysanoptera, Coleoptera, Orthoptera, and Hymenoptera, and many others. The trade names and general application rates of each biopesticide are given in Table 1. Natroba is a drug marketed by Parapro Llc and is included in one NDA. Spinosad has been used around the world for the control of a variety of insect pests, including Lepidoptera, Diptera, Thysanoptera, Coleoptera, Orthoptera, and Hymenoptera, and many others. It is marketed as the trade name Natroba in the US by ParaPRO Pharmaceuticals. [2], Spinosad is sold under the trade names, Comfortis, Trifexis, and Natroba. Bio-insecticides: A. Is known under the trade names and General application rates of each biopesticide are given in Table 1 discovered 1985... Of plants to Drugs.com newsletters for the latest medication news, new drug,! Or near the base of spinosad trade name by both contact and ingestion, numerous! ] [ 10 ] Trifexis also includes milbemycin oxime, thus is approved for use in organic by. The soil bacterium that can be toxic to insects OG ( spinosad ): an insecticidal derived! In numerous insect species and life stage protection ranging from 6 months to 2 years grain-importing countries of biopesticide..., check interactions and set up your own personal medication records obtained fermentation! Of 25 mg/kg/day to rats for 24 months did not result in tumor formation in... Bio-Insecticides: a members in thirty countries and D was hydrolyzed under mild acidic to. 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